The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina.

Abstract

Complexins (Cplxs) regulate the speed and Ca(2+)-sensitivity of synaptic vesicle fusion. It has been shown that all four known Cplxs are present at mouse retinal synapses--at conventional amacrine cell synapses (Cplx 1 to Cplx 3) and at photoreceptor and bipolar cell ribbon synapses (Cplx 3 and Cplx 4) [K. Reim et al. (2005) J. Cell Biol., 169, 669-680… (More)
DOI: 10.1111/j.1460-9568.2012.08149.x

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