The absence of 5-HT1A receptors has minor effects on dopamine but not serotonin release evoked by MK-801 in mice prefrontal cortex

@article{Castane2008TheAO,
  title={The absence of 5-HT1A receptors has minor effects on dopamine but not serotonin release evoked by MK-801 in mice prefrontal cortex},
  author={A. Castane and Francesc Casa{\~n}as Artigas and Anal{\'i}a Bortolozzi},
  journal={Psychopharmacology},
  year={2008},
  volume={200},
  pages={281-290}
}
Non-competitive NMDA receptor antagonists markedly increase neuronal activity in medial prefrontal cortex (mPFC), an effect which partly underlies their schizomimetic actions. Projection pyramidal neurons and local GABAergic interneurons in mPFC express 5-HT1A receptors, whose activation modulates dopaminergic (DA) and serotonergic (5-HT) activity in midbrain and the cortical release of both monoamines. To examine whether the presence of 5-HT1A receptors can modulate the effect of NMDA receptor… CONTINUE READING
7 Citations
86 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 86 references

The mouse brain in stereotaxic coordinates

  • K Franklin, G Paxinos
  • 1997
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…