The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.

Abstract

BACKGROUND Mutations in the MYH9 gene cause autosomal dominant MYH9-related diseases (MYH9-RD) that associate macrothrombocytopenia with various other clinical conditions. The mechanisms giving rise to giant platelets remain poorly understood. OBJECTIVES/PATIENTS To study the proplatelet formation (PPF) derived from megakaryocytes (MKs) generated in vitro… (More)
DOI: 10.1111/jth.12436

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