The abnormal development of drive and guidance mechanisms in the brain: the pathogenesis of schizophrenia.

BACKGROUND It remains a mystery as to how genetic and environmental factors cause schizophrenia. OBJECTIVE To develop a pathophysiological model of schizophrenia that has greater explanatory power than existing hypotheses of the disorder. METHOD Published findings on schizophrenia are integrated with more recent data from human and animal studies of… CONTINUE READING