The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice

@article{Sansom2002TheAT,
  title={The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice},
  author={Owen James Sansom and Alan R. Clarke},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={5934-5939}
}
Apoptosis and long term enterocyte survival were examined in vivo after exposure to three cytotoxic agents (Cisplatin, Nitrogen Mustard and N-methyl-N-nitrosourea (NMNU/MNU)) within mice either singly or doubly mutant for p53 and Msh2. P53 deficiency caused abrogation of the immediate apoptotic response to each agent, but only led to increased survival after cisplatin treatment. Msh2 deficiency reduced the apoptotic response to each agent, but only led to increased crypt survival after NMNU… CONTINUE READING

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