The ability of the Comet assay to discriminate between genotoxins and cytotoxins.

  title={The ability of the Comet assay to discriminate between genotoxins and cytotoxins.},
  author={Leigh Henderson and Alison Wolfreys and J K Fedyk and C Bourner and S Windebank},
  volume={13 1},
The Comet assay has been used widely in genetic toxicology, radiation biology and medical and environmental research. This assay detects single-strand breaks and alkali-labile sites in DNA and DNA degradation due to necrosis or apoptosis. It may also be modified to detect DNA cross-linking. Although a considerable number of chemicals have been tested in the assay there are many aspects of validation to be considered before the method could be considered to provide definitive evidence of… CONTINUE READING
Highly Cited
This paper has 151 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 70 extracted citations

Understanding aging.

Methods in molecular medicine • 2000
View 9 Excerpts
Highly Influenced

151 Citations

Citations per Year
Semantic Scholar estimates that this publication has 151 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 26 references

Detection of DNAcross - linking agents with the alkaline Comet assay

S. Pfuhler, U. Wolf.H.
Environ . Mol . Mutagen . • 1996

Genotoxicity of the laxative drug components emodin , aloeemodin and danthron in mammalian cells : topoisomerase II mediated ?

O. Muller.S., L Eckert, W. K. Lutz, H. Stopper
Mutat . Res . • 1996