The ability of the Comet assay to discriminate between genotoxins and cytotoxins.

@article{Henderson1998TheAO,
  title={The ability of the Comet assay to discriminate between genotoxins and cytotoxins.},
  author={Leigh Henderson and Alison Wolfreys and J K Fedyk and C Bourner and S Windebank},
  journal={Mutagenesis},
  year={1998},
  volume={13 1},
  pages={
          89-94
        }
}
The Comet assay has been used widely in genetic toxicology, radiation biology and medical and environmental research. This assay detects single-strand breaks and alkali-labile sites in DNA and DNA degradation due to necrosis or apoptosis. It may also be modified to detect DNA cross-linking. Although a considerable number of chemicals have been tested in the assay there are many aspects of validation to be considered before the method could be considered to provide definitive evidence of… CONTINUE READING
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