The ability of four genotypic interpretation systems to predict virological response to ritonavir-boosted protease inhibitors.

@article{Fox2007TheAO,
  title={The ability of four genotypic interpretation systems to predict virological response to ritonavir-boosted protease inhibitors.},
  author={Zoe V. Fox and Anna Mar{\'i}a Geretti and Jesper Kjaer and Ulrik Bak Dragsted and Andrew N Phillips and Jan Gerstoft and Schlomo Staszewski and Bonaventura Clotet and Viktor von Wyl and Jens D. Lundgren},
  journal={AIDS},
  year={2007},
  volume={21 15},
  pages={2033-42}
}
BACKGROUND : Limited information exists on the prognostic value of genotypic interpretation systems (GISs) for ritonavir-boosted protease inhibitors (PI/rs). We compared PI/r resistance levels ascribed by four GIS and examined their abilities to predict HIV-RNA reductions after starting a PI/r-based regimen (baseline). METHODS : Data on viraemic (HIV-RNA > 500 copies/ml) patients starting a PI/r with a baseline resistance test were combined from an observational cohort study (EuroSIDA) and… CONTINUE READING

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