The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

@inproceedings{Fricke2013TheAO,
  title={The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6},
  author={Thomas Fricke and Jos{\'e} Carlos Valle-Casuso and Tommy E. White and Alberto Brandariz-Nu{\~n}ez and William J Bosche and Natalia Reszka and Robert J. Gorelick and Felipe Diaz-Griffero},
  booktitle={Retrovirology},
  year={2013}
}
BackgroundExpression of the cellular karyopherin TNPO3/transportin-SR2/Tnp3 is necessary for HIV-1 infection. Depletion of TNPO3 expression in mammalian cells inhibits HIV-1 infection after reverse transcription but prior to integration.ResultsThis work explores the role of cleavage and polyadenylation specificity factor subunit 6 (CPSF6) in the ability of TNPO3-depleted cells to inhibit HIV-1 infection. Our findings showed that depletion of TNPO3 expression inhibits HIV-1 infection, while the… CONTINUE READING

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