The ability of Sephadex to activate human complement is suppressed in specifically substituted functional Sephadex derivatives.

@article{Carreno1988TheAO,
  title={The ability of Sephadex to activate human complement is suppressed in specifically substituted functional Sephadex derivatives.},
  author={M P Carreno and Denis Labarre and Marcel Jozefowicz and Michel Daniel Kazatchkine},
  journal={Molecular immunology},
  year={1988},
  volume={25 2},
  pages={165-71}
}
The capacity of Sephadex and of chemically substituted Sephadex derivatives to activate human complement was examined by incubating polymer particles in normal human serum (NHS) under conditions that allow classical and/or alternative pathway activation, and by determining complement consumption or generation of C3a antigen in serum. Sephadex was found to activate complement in NHS, mainly through the alternative pathway. The complement-activating capacity of Sephadex was directly related to… CONTINUE READING