The aadB gene cassette is associated with blaSHV genes in Klebsiella species producing extended-spectrum beta-lactamases.

@article{Jones2005TheAG,
  title={The aadB gene cassette is associated with blaSHV genes in Klebsiella species producing extended-spectrum beta-lactamases.},
  author={Louisa A. Jones and Christopher J. Mciver and M Y Kim and William D Rawlinson and Peter A White},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 2},
  pages={794-7}
}
Integrons were detected in 37 (72.5%) of 51 Klebsiella spp. producing extended-spectrum beta-lactamases by PCR with primers that targeted integrase genes and cassette regions. PCR and amplicon sequencing of the cassette regions revealed aadB and aadA2 gene cassettes that confer resistance to a range of aminoglycosides. aadB was associated with a class 1 integron on a 28-kb plasmid, pES1, that also contained bla(SHV-12) and IS26. 
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