The a Chemokine , Interleukin 8 , Inhibits the Antiviral Action of Interferon


Interferon (IFN) exhibits a potent antiviral activity in vitro and plays a major role in the early defense against viruses . Like IFN, the proinflammatory chemokine, interleukin (IL)-8, is induced by viruses and appears in circulation during viral infections. In an in vitro cytopathic effect assay for IFN, we found that IL-8 can inhibit IFNa activity in a… (More)


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