The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.

@article{Lian2018TheZP,
  title={The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.},
  author={Huan Lian and Ru Zang and Jin Wei and W. B. Ye and Ming-Ming Hu and Yun-Da Chen and Xianan Zhang and Yi Guo and Cao-Qi Lei and Qing Yang and Wei-Wei Luo and Shu Li and Hong-Bing Shu},
  journal={Immunity},
  year={2018},
  volume={49 3},
  pages={
          438-448.e5
        }
}
Recognition of viral RNA by the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) initiates innate antiviral immune response. How the binding of viral RNA to and activation of the RLRs are regulated remains enigmatic. In this study, we identified ZCCHC3 as a positive regulator of the RLRs including RIG-I and MDA5. ZCCHC3 deficiency markedly inhibited RNA virus-triggered induction of downstream antiviral genes, and ZCCHC3-deficient mice were more susceptible to RNA virus infection… CONTINUE READING
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