The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

@inproceedings{Moldovan2015TheZA,
  title={The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition},
  author={John B. Moldovan and John V Moran},
  booktitle={PLoS genetics},
  year={2015}
}
Long INterspersed Element-1 (LINE-1 or L1) is the only active autonomous retrotransposon in the human genome. To investigate the interplay between the L1 retrotransposition machinery and the host cell, we used co-immunoprecipitation in conjunction with liquid chromatography and tandem mass spectrometry to identify cellular proteins that interact with the L1 first open reading frame-encoded protein, ORF1p. We identified 39 ORF1p-interacting candidate proteins including the zinc-finger antiviral… CONTINUE READING