The Zic family homologue Odd-paired regulates Alk expression in Drosophila

  title={The Zic family homologue Odd-paired regulates Alk expression in Drosophila},
  author={Patricia Mendoza-Garc{\'i}a and Fredrik Hugosson and Mahsa Fallah and Michael L Higgins and Yasuno Iwasaki and Kathrin Pfeifer and Georg Wolfstetter and Gaurav K. Varshney and Dmitry Popichenko and J Peter Gergen and Korneel Hens and Bart Deplancke and Ruth H Palmer},
  booktitle={PLoS genetics},
The Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) plays a critical role in the specification of founder cells (FCs) in the Drosophila visceral mesoderm (VM) during embryogenesis. Reporter gene and CRISPR/Cas9 deletion analysis reveals enhancer regions in and upstream of the Alk locus that influence tissue-specific expression in the amnioserosa (AS), the VM and the epidermis. By performing high throughput yeast one-hybrid screens (Y1H) with a library of Drosophila transcription… CONTINUE READING
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