The Zebrafish as a New Model for the In Vivo Study of Shigella flexneri Interaction with Phagocytes and Bacterial Autophagy

@inproceedings{Mostowy2013TheZA,
  title={The Zebrafish as a New Model for the In Vivo Study of Shigella flexneri Interaction with Phagocytes and Bacterial Autophagy},
  author={Serge Mostowy and Laurent Boucontet and Maria J. Mazon Moya and Andrea Sirianni and Pierre Boudinot and Michael S. Hollinshead and Pascale Cossart and Philippe Herbomel and J. -P. Levraud and Emma Colucci-Guyon},
  booktitle={PLoS pathogens},
  year={2013}
}
Autophagy, an ancient and highly conserved intracellular degradation process, is viewed as a critical component of innate immunity because of its ability to deliver cytosolic bacteria to the lysosome. However, the role of bacterial autophagy in vivo remains poorly understood. The zebrafish (Danio rerio) has emerged as a vertebrate model for the study of infections because it is optically accessible at the larval stages when the innate immune system is already functional. Here, we have… CONTINUE READING
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