The ZIC gene family in development and disease.

  title={The ZIC gene family in development and disease.},
  author={Inessa Grinberg and Kathleen J. Millen},
  journal={Clinical genetics},
  volume={67 4},
The human ZIC gene family is comprised of five members encoding zinc-finger transcription factors, which are the vertebrate homologs of the Drosophila odd-paired gene. Mutations in ZIC genes in humans have recently been implicated in a wide variety of congenital malformations, including Dandy-Walker malformation, holoprosencephaly, neural tube defects, and heterotaxy. Mutant analysis of these genes in mice has underscored the conserved developmental roles of these genes. Further, this analysis… CONTINUE READING