The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis

@article{Houtmeyers2013TheZG,
  title={The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis},
  author={Rob Houtmeyers and Jacob Souopgui and Sabine Tejpar and Ruth M Arkell},
  journal={Cellular and Molecular Life Sciences},
  year={2013},
  volume={70},
  pages={3791-3811}
}
The zinc finger of the cerebellum gene (ZIC) discovered in Drosophila melanogaster (odd-paired) has five homologs in Xenopus, chicken, mice, and humans, and seven in zebrafish. This pattern of gene copy expansion is accompanied by a divergence in gene and protein structure, suggesting that Zic family members share some, but not all, functions. ZIC genes are implicated in neuroectodermal development and neural crest cell induction. All share conserved regions encoding zinc finger domains… CONTINUE READING
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Zinc fingers of the cerebellum (Zic): transcription factors and co-factors.

The international journal of biochemistry & cell biology • 2012
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