The ZEB1 Transcription Factor Is a Novel Repressor of Adiposity in Female Mice

@inproceedings{Saykally2009TheZT,
  title={The ZEB1 Transcription Factor Is a Novel Repressor of Adiposity in Female Mice},
  author={Jessica N. Saykally and Soner Dogan and Margot P. Cleary and Michel M. Sanders},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Four genome-wide association studies mapped an "obesity" gene to human chromosome 10p11-12. As the zinc finger E-box binding homeobox 1 (ZEB1) transcription factor is encoded by the TCF8 gene located in that region, and as it influences the differentiation of various mesodermal lineages, we hypothesized that ZEB1 might also modulate adiposity. The goal of these studies was to test that hypothesis in mice. METHODOLOGY/PRINCIPAL FINDINGS To ascertain whether fat accumulation affects… CONTINUE READING

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