The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.

  title={The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.},
  author={Simone Brabletz and Karolina Bajdak and Simone Meidhof and Ulrike C. Burk and Gabriele Niedermann and Elke Firat and U. Wellner and Arno Dimmler and Gerhard Faller and Joerg Schubert and T. Brabletz},
  journal={The EMBO journal},
  volume={30 4},
Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components are rare in solid tumours. ZEB1 is an activator of an epithelial-mesenchymal transition (EMT) and has crucial roles in tumour progression towards metastasis. ZEB1 and miR-200 family members repress expression of each other in a reciprocal feedback loop. Since miR-200 members target stem cell factors, ZEB1 indirectly induces stemness… CONTINUE READING


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