The Yin and Yang of nucleic acid-based therapy in the brain

@article{Gustincich2017TheYA,
  title={The Yin and Yang of nucleic acid-based therapy in the brain},
  author={Stefano Gustincich and Silvia Zucchelli and Antonello Mallamaci},
  journal={Progress in Neurobiology},
  year={2017},
  volume={155},
  pages={194-211}
}
The post-genomic era has unveiled the existence of a large repertory of non-coding RNAs and repetitive elements that play a fundamental role in cellular homeostasis and dysfunction. These may represent unprecedented opportunities to modify gene expression at the right time in the correct space in vivo, providing an almost unlimited reservoir of new potential pharmacological agents. Hijacking their mode of actions, the druggable genome can be extended to regulatory RNAs and DNA elements in a… CONTINUE READING

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