The Yin and Yang of NMDA receptor signalling

@article{Hardingham2003TheYA,
  title={The Yin and Yang of NMDA receptor signalling},
  author={G. Hardingham and H. Bading},
  journal={Trends in Neurosciences},
  year={2003},
  volume={26},
  pages={81-89}
}
Ca(2+) entry through the NMDA subtype of glutamate receptors has the power to determine whether neurons survive or die. Too much NMDA receptor activity is harmful to neurons - but so is too little. Is it a case of too much or too little Ca(2+) influx causing cell death or do other factors, such as receptor location or receptor-associated proteins, play a role? Understanding the mechanisms behind this dichotomous signalling is an important area of molecular neuroscience with direct clinical… Expand
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