The Yin and Yang aspects of IL-27 in induction of cancer-specific T-cell responses and immunotherapy.

Abstract

Accumulating evidences from animal studies have indicated that both endogenous and exogenous IL-27, an IL-12 family of cytokine, can increase antitumor T-cell activities and inhibit tumor growth. IL-27 can modulate Treg responses, and program effector T cells into a unique T-effector stem cell (TSEC) phenotype, which enhances T-cell survival in the tumor… (More)
DOI: 10.2217/imt.14.95

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Cite this paper

@article{Li2015TheYA, title={The Yin and Yang aspects of IL-27 in induction of cancer-specific T-cell responses and immunotherapy.}, author={Ming-song Li and Zhenzhen Liu and Jin-qing Liu and Xiaotong Zhu and Zhihao Liu and Xue-Feng Bai}, journal={Immunotherapy}, year={2015}, volume={7 2}, pages={191-200} }