The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance.


An intrinsic (oncogene-driven) pathway and an extrinsic (microenvironment-driven) pathway connect inflammatory reactions and cancer. M2-polarized tumor-associated macrophages and the related myeloid-derived suppressor cells are key prototypic components of smoldering inflammation driving neoplastic progression. However, mononuclear phagocytes can exert anti… (More)
DOI: 10.1111/j.1600-065X.2008.00607.x


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