The Yersinia pestis HmsCDE regulatory system is essential for blockage of the oriental rat flea (Xenopsylla cheopis), a classic plague vector.

@article{Bobrov2015TheYP,
  title={The Yersinia pestis HmsCDE regulatory system is essential for blockage of the oriental rat flea (Xenopsylla cheopis), a classic plague vector.},
  author={Alexander G. Bobrov and O. V. Kirillina and Viveka Vadyvaloo and Benjamin J Koestler and Angela K. Hinz and Dietrich Mack and Christopher M. Waters and Robert D. Perry},
  journal={Environmental microbiology},
  year={2015},
  volume={17 4},
  pages={
          947-59
        }
}
The second messenger molecule cyclic diguanylate is essential for Yersinia pestis biofilm formation that is important for blockage-dependent plague transmission from fleas to mammals. Two diguanylate cyclases (DGCs) HmsT and Y3730 (HmsD) are responsible for biofilm formation in vitro and biofilm-dependent blockage in the oriental rat flea Xenopsylla cheopis respectively. Here, we have identified a tripartite signalling system encoded by the y3729-y3731 operon that is responsible for regulation… CONTINUE READING
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