The Y2 receptor mediates increases in collateral-dependent blood flow in a model of peripheral arterial insufficiency.

Abstract

We have utilized a rat model of peripheral artery disease (PAD) to examine whether the known angiogenic activity of the Y(2) receptor would translate into a meaningful increase in collateral blood flow. The maximal increase in collateral blood flow capacity of approximately 60% (p<0.001) was obtained with a 10microg/kgday (IA infusion, 14 days) of either PYY or PYY(3-36) and did not differ from that obtained with a maximally angiogenic dose of VEGF(165). Pharmacodynamic modeling based upon single dose pharmacokinetic plasma profiles of both agonists suggests that E(max) is reached when the Y(2) receptor is occupied by >or=50%. Furthermore, for PYY(3-36), occupancy of the Y(2) receptor is sufficient to promote a significant benefit in collateral blood flow.

Cite this paper

@article{Cruze2007TheYR, title={The Y2 receptor mediates increases in collateral-dependent blood flow in a model of peripheral arterial insufficiency.}, author={Charles A. Cruze and Frank Chih-Wei Su and Brian J. Limberg and Angela J Deutsch and Peter J Stoffolano and Hong Jian Dai and Danielle D Buchanan and Hsiao T. Yang and Ronald L. Terjung and Russell D Spruell and Scott W. Mittelstadt and Jan S. Rosenbaum}, journal={Peptides}, year={2007}, volume={28 2}, pages={269-80} }