The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells.

Abstract

X-chromosome inactivation (XCI) is initiated by the long noncoding RNA Xist, which coats the inactive X (Xi) and targets Polycomb repressive complex 2 (PRC2) in cis. Epigenomic analyses have provided significant insight into Xist binding patterns and chromatin organization of the Xi. However, such epigenomic analyses are limited by averaging of population… (More)
DOI: 10.1073/pnas.1503690112

Topics

8 Figures and Tables

Cite this paper

@article{Sunwoo2015TheXR, title={The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells.}, author={Hongjae Sunwoo and John Y.C. Wu and Jeannie T Lee}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2015}, volume={112 31}, pages={E4216-25} }