The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly.

@article{Roghi1998TheXP,
  title={The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly.},
  author={Christian Roghi and R{\'e}gis Giet and Rustem E Uzbekov and Nathalie Morin and Isabelle Chartrain and Ren{\'e} Le Guellec and Anne Couturier and Marcel Dor{\'e}e and Michel Chignard Philippe and Claude Prigent},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 5)},
  pages={557-72}
}
By differential screening of a Xenopus laevis egg cDNA library, we have isolated a 2,111 bp cDNA which corresponds to a maternal mRNA specifically deadenylated after fertilisation. This cDNA, called Eg2, encodes a 407 amino acid protein kinase. The pEg2 sequence shows significant identity with members of a new protein kinase sub-family which includes Aurora from Drosophila and Ipl1 (increase in ploidy-1) from budding yeast, enzymes involved in centrosome migration and chromosome segregation… CONTINUE READING
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