The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions.

@article{Pannese1995TheXH,
  title={The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions.},
  author={Maria Pannese and Cristiana Polo and Massimiliano Andreazzoli and Robert Vignali and Boris Kablar and Giuseppina Barsacchi and E. Boncinelli},
  journal={Development},
  year={1995},
  volume={121 3},
  pages={707-20}
}
In this paper we study Xotx2, a Xenopus homeobox gene related to orthodenticle, a gene expressed in the developing head of Drosophila. The murine cognate, Otx2, is first expressed in the entire epiblast of prestreak embryos and later in very anterior regions of late-gastrulae, including the neuroectoderm of presumptive fore- and mid-brain. In Xenopus, RNase protection experiments reveal that Xotx2 is expressed at low levels throughout early development from unfertilized egg to late blastula… CONTINUE READING
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