The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis.

@article{Jiang1996TheXG,
  title={The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis.},
  author={Yangfu Jiang and Todd Evans},
  journal={Developmental biology},
  year={1996},
  volume={174 2},
  pages={258-70}
}
The GATA family of nuclear factors has been implicated in the regulation of cell type-specific transcription. We report the isolation of the Xenopus GATA-4 and GATA-6 cDNA clones and characterize the expression patterns of the xGATA-4/5/6 genes. By comparing the sequence of the cDNAs with those previously reported from chick and mammalian sources, we conclude that each is conserved across vertebrate evolution as a distinct gene product. Each gene is expressed in differentiated adult heart and… CONTINUE READING