The XbaI G>T polymorphism of the glucose transporter 1 gene modulates 18F-FDG uptake and tumor aggressiveness in breast cancer.

@article{Grabellus2010TheXG,
  title={The XbaI G>T polymorphism of the glucose transporter 1 gene modulates 18F-FDG uptake and tumor aggressiveness in breast cancer.},
  author={Florian Grabellus and S Sheu and Hagen Sjard Bachmann and Nils Lehmann and Friedrich Otterbach and Till Alexander Heusner and Gerald Antoch and Andreas Bockisch and Rainer Kimmig and Kurt Werner Schmid and Alexander R. Stahl},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2010},
  volume={51 8},
  pages={1191-7}
}
UNLABELLED We investigated the relevance of single-nucleotide polymorphisms (SNPs) in the glucose transporter 1 (GLUT1) gene to the uptake of (18)F-FDG and tumor aggressiveness in breast cancer. METHODS In 52 individuals with breast cancer, a diagnostic PET/CT scan was obtained, and the standardized uptake value was determined as a measure of (18)F-FDG uptake using a region-of-interest technique. Three GLUT1 SNPs (XbaI G>T, HpyCH4V A>T, and HaeIII T>C) were investigated in genomic DNA that… CONTINUE READING

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