The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase.

@article{Leber1998TheXG,
  title={The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase.},
  author={Regina Leber and Teresa W. Wise and Ryushin Mizuta and Katheryn Rhoads Meek},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 3},
  pages={
          1794-801
        }
}
The gene product of XRCC4 has been implicated in both V(D)J recombination and the more general process of double strand break repair (DSBR). To date its role in these processes is unknown. Here, we describe biochemical characteristics of the murine XRCC4 protein. XRCC4 expressed in insect cells exists primarily as a disulfide-linked homodimer, although it can also form large multimers. Recombinant XRCC4 is phosphorylated during expression in insect cells. XRCC4 phosphorylation in Sf9 cells… CONTINUE READING
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