The XRCC1 -77T->C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage.

@article{Brem2006TheX,
  title={The XRCC1 -77T->C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage.},
  author={Reto Brem and David G. Cox and Brigitte Chapot and Norman Moullan and Pascale Romestaing and J N Gerard and Paola Pisani and Janet Hall},
  journal={Carcinogenesis},
  year={2006},
  volume={27 12},
  pages={
          2469-74
        }
}
X-ray repair cross-complementing 1 (XRCC1) is required for single-strand break repair in human cells and several polymorphisms in this gene have been implicated in cancer risk and clinical prognostic factors. We examined the frequency of the 5'-untranslated region (5'-UTR) variant -77T-->C (rs 3213235) in 247 French breast cancer (BC) patients, 66 of whom were adverse radiotherapy responders, and 380 controls and determined the haplotypes based on this and the previously genotyped variants… CONTINUE READING
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A functional −77T>C polymorphism in XRCC1 is associated with risk of breast cancer

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