The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung.

@article{Divine2001TheX3,
  title={The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung.},
  author={Kevin K. Divine and Frank D Gilliland and Richard E. Crowell and Christine A. Stidley and Theresa J Bocklage and Dennis L. Cook and Steven Alan Belinsky},
  journal={Mutation research},
  year={2001},
  volume={461 4},
  pages={273-8}
}
Defects in the repair and maintenance of DNA increase risk for cancer. X-ray cross-complementing group 1 protein (XRCC1) is involved with the repair of DNA single-strand breaks. A nucleotide substitution of guanine to adenine leading to a non-conservative amino acid change was identified in the XRCC1 gene at codon 399 (Arg/Gln). This change is associated with higher levels of aflatoxin B1-adducts and glycophorin A somatic mutations. A case-control study was conducted to test the hypothesis that… CONTINUE READING