The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development

@inproceedings{Qi2010TheXG,
  title={The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development},
  author={Hank Heng Qi and Madathia Sarkissian and Gang-Qing Hu and Zhibin Wang and Arindam Bhattacharjee and D. Benjamin Gordon and Michelle Gonzales and Fei Lan and Pat P. Ongusaha and Maite Huarte and Nasser Khaled Yaghi and Huijun Lim and Benjamin A Garcia and Leonardo Brizuela and Keji Zhao and Thomas M Roberts and Yang Shi},
  booktitle={Nature},
  year={2010}
}
X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability. Causal mutations have been found in approximately 90 X-linked genes; however, molecular and biological functions of many of these genetically defined XLMR genes remain unknown. PHF8 (PHD (plant homeo domain) finger protein 8) is a JmjC domain-containing protein and its mutations have been found in patients with XLMR and craniofacial deformities. Here we provide multiple lines of evidence… CONTINUE READING
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Structural insights into a novel histone demethylase PHF8

  • L Yu
  • Cell Res
  • 2010

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