The X-ray structure of an anti-tumour antibody in complex with antigen

@article{Jeffrey1995TheXS,
  title={The X-ray structure of an anti-tumour antibody in complex with antigen},
  author={Philip D. Jeffrey and J{\"u}rgen Bajorath and Chiehying Y Chang and Dale E. Yelton and Ingegerd Hellstroem and Karl Erik Hellstroem and Steven Sheriff},
  journal={Nature Structural Biology},
  year={1995},
  volume={2},
  pages={466-471}
}
The crystal structures of the murine BR96 Fab and its human chimera have been determined in complex with the nonoate methyl ester derivative of Lewis Y (nLey) at 2.8 Å and 2.5 Å resolution, respectively. BR96 binds the carbohydrate in a large pocket which is formed by residues of all CDR loops except L2. The binding of the carbohydrate is mediated predominantly by aromatic residues in BR96. Analysis of the structure suggests that BR96 is capable of recognizing a structure larger than the Ley… CONTINUE READING
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