The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

  title={The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1},
  author={D. Picot and P. Loll and R. Garavito},
  • D. Picot, P. Loll, R. Garavito
  • Published 1994
  • Chemistry, Medicine
  • Nature
  • The three-dimensional structure of prostaglandin H2 synthase-1, an integral membrane protein, has been determined at 3.5 Å resolution by X-ray crystallography. This bifunctional enzyme comprises three independent folding units: an epidermal growth factor domain, a membrane-binding motif and an enzymatic domain. Two adjacent but spatially distinct active sites were found for its haem-dependent peroxidase and cyclooxygenase activities. The cyclooxygenase active site is created by a long… CONTINUE READING
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