The X protein of hepatitis B virus coactivates potent activation domains.

@article{Haviv1995TheXP,
  title={The X protein of hepatitis B virus coactivates potent activation domains.},
  author={Izhak Haviv and D Vaizel and Yosef Shaul},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 2},
  pages={1079-85}
}
Transactivation by hepatitis B virus X protein (pX) is promiscuous, but it requires cellular activators. To study the mode of action of pX, we coexpressed pX with Gal4-derived activators in a cotransfection system. Twelve different activators bearing different types of activation domains were compared for their response to pX. Because pX indirectly increases the amount of the activators, tools were developed to compare samples with equivalent amount of activators. We demonstrate that pX… CONTINUE READING