The X chromosome in quantitative trait locus mapping.

  title={The X chromosome in quantitative trait locus mapping.},
  author={Karl W. Broman and Saunak Sen and Sarah E Owens and Ani Manichaikul and E. Michelle Southard-Smith and Gary A. Churchill},
  volume={174 4},
The X chromosome requires special treatment in the mapping of quantitative trait loci (QTL). However, most QTL mapping methods, and most computer programs for QTL mapping, have focused exclusively on autosomal loci. We describe a method for appropriate treatment of the X chromosome for QTL mapping in experimental crosses. We address the important issue of formulating the null hypothesis of no linkage appropriately. If the X chromosome is treated like an autosome, a sex difference in the… CONTINUE READING
Highly Cited
This paper has 43 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 26 extracted citations

A major X-linked locus affects kidney function in mice

Molecular Genetics and Genomics • 2012
View 2 Excerpts
Highly Influenced

The importance of having two X chromosomes.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2016