The X chromosome in quantitative trait locus mapping.

@article{Broman2006TheXC,
  title={The X chromosome in quantitative trait locus mapping.},
  author={Karl W. Broman and Saunak Sen and Sarah E Owens and Ani Manichaikul and E. Michelle Southard-Smith and Gary A. Churchill},
  journal={Genetics},
  year={2006},
  volume={174 4},
  pages={
          2151-8
        }
}
The X chromosome requires special treatment in the mapping of quantitative trait loci (QTL). However, most QTL mapping methods, and most computer programs for QTL mapping, have focused exclusively on autosomal loci. We describe a method for appropriate treatment of the X chromosome for QTL mapping in experimental crosses. We address the important issue of formulating the null hypothesis of no linkage appropriately. If the X chromosome is treated like an autosome, a sex difference in the… CONTINUE READING
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