The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response.

@article{Iwakoshi2003TheXB,
  title={The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response.},
  author={Neal N. Iwakoshi and Ann-Hwee Lee and L. H. Glimcher},
  journal={Immunological reviews},
  year={2003},
  volume={194},
  pages={29-38}
}
X-box binding protein-1 (XBP-1) is a transcription factor essential for plasma cell differentiation. XBP-1 transcripts are found at high levels in plasma cells from rheumatoid synovium and myeloma cell lines. Lymphoid chimeras deficient in XBP-1 have a profound defect in plasma cell differentiation, with few plasma cells in their periphery and severely reduced serum immunoglobulin levels. When introduced into B-lineage cells, XBP-1 initiates plasma cell differentiation. XBP-1 is also the… CONTINUE READING