The X Gene of Adeno-Associated Virus 2 (AAV2) Is Involved in Viral DNA Replication

@inproceedings{Cao2014TheXG,
  title={The X Gene of Adeno-Associated Virus 2 (AAV2) Is Involved in Viral DNA Replication},
  author={Maohua Cao and Hong You and Paul L. Hermonat},
  booktitle={PloS one},
  year={2014}
}
Adeno-associated virus (AAV) (type 2) is a popular human gene therapy vector with a long active transgene expression period and no reported vector-induced adverse reactions. Yet the basic molecular biology of this virus has not been fully addressed. One potential gene at the far 3' end of the AAV2 genome, previously referred to as X (nt 3929 to 4393), overlapping the 3' end of the cap gene, has never been characterized, although we did previously identify a promoter just up-stream (p81… CONTINUE READING