The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms

@article{Velnar2009TheWH,
  title={The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms},
  author={Toma{\vz} Velnar and Tracey Bailey and Vladimir Smrkolj},
  journal={Journal of International Medical Research},
  year={2009},
  volume={37},
  pages={1528 - 1542}
}
Wound healing remains a challenging clinical problem and correct, efficient wound management is essential. Much effort has been focused on wound care with an emphasis on new therapeutic approaches and the development of technologies for acute and chronic wound management. Wound healing involves multiple cell populations, the extracellular matrix and the action of soluble mediators such as growth factors and cytokines. Although the process of healing is continuous, it may be arbitrarily divided… 
Wound healing: cellular mechanisms and pathological outcomes
TLDR
The cellular basis of tissue repair is reviewed and how current and emerging understanding of wound pathology could inform future development of efficacious wound therapies are discussed.
Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration
TLDR
This comprehensive review focuses on the progress in wound medication and how it has evolved over the years, and advanced treatment strategies for skin regeneration and experimental techniques for cellular engineering and skin tissue engineering are addressed.
Biotechnological Approaches to Hemostasis and Molecular Mechanisms of Wound Healing
TLDR
Normal wound healing is a dynamic and complex process involving a series of coordinated events, including bleeding, coagulation, initiation of an acute inflammatory response to the initial injury, regeneration, migration and proliferation of connective tissue and parenchyma cells, as well as synthesis of extracellular matrix proteins.
Approach to Wound Healing
TLDR
This review summarizes the current information regarding wound healing responses and explain the underlying pathophysiology of wound healing process.
Using Stem Cells to Promote Wound Healing: An Emerging Solution for a Clinical Problem
TLDR
In this chapter, the in vivo role of stem cells and the stem cell niche during the wound healing process is reviewed to provide a context for potential exogenous stem cell therapeutic applications, as well as explore some of the recent evidence that supports improved healing and tissue regeneration.
Nanomaterial-Based Therapy for Wound Healing
TLDR
The present article highlights the mechanism and pathophysiology of wound healing, and discusses the current findings concerning the prospects and challenges of nanomaterial usage in the management of chronic wounds.
Mechanisms of Collective Cell Migration in Wound Healing: Physiology and Disease
TLDR
Parts of mechanisms of wound healing, collective cell migration, and the factors affecting wound healing are described, which would help design and develop better therapeutics for the same and help in improvement of health.
Insulin and wound healing.
...
...

References

SHOWING 1-10 OF 102 REFERENCES
The Basic Science of Wound Healing
TLDR
This article will attempt to provide a concise report of the current literature on wound healing by first reviewing the phases of wound healing followed by “the players” of wounds healing: inflammatory mediators (cytokines, growth factors, proteases, eicosanoids, kinins, and more), nitric oxide, and the cellular elements.
Wound healing: an overview of acute, fibrotic and delayed healing.
TLDR
This review describes the major biological processes associated with both normal and pathologic healing of acute wounds, characterized by four distinct, but overlapping phases: hemostasis, inflammation, proliferation and remodeling.
[The modern approach to wound treatment].
TLDR
Conventional methods of local wound treatment (mechanical cleansing, disinfection with antiseptic solutions, wound debridement--surgical, biological and autolytic; wound closure, topical antibiotic treatment, dressing) as well as general measures are presented.
General principles of wound healing.
Advances in Wound Care and Healing Technology
TLDR
This article reviews advances made in wound care management over the years and concludes that basic principles of wound care in a multidisciplinary team setting still remain the backbone of wound management.
Normal Cutaneous Wound Healing: Clinical Correlation with Cellular and Molecular Events
  • C. BaumC. Arpey
  • Medicine, Biology
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2005
TLDR
Cutaneous wound healing in normal hosts follows an orderly clinical process, and the scientific underpinnings for healing are better understood than ever, although much remains to be discovered.
Wound healing: an overview.
TLDR
This article will attempt to provide a concise overview on wound healing and wound management.
Growth Factors and Chronic Wound Healing: Past, Present, and Future
  • R. Goldman
  • Biology, Medicine
    Advances in skin & wound care
  • 2004
TLDR
Based on dramatic preclinical animal studies, a phase 1 clinical trial planned on a PDGF genetic construct appears promising, and a single application will induce constitutive growth factor expression for weeks.
Modern Wound Dressings: A Systematic Approach to Wound Healing
TLDR
A critical review of the current status of technology and the worldwide opportunities for improved wound management products is provided, focused on the clinical applications of the newer, breathable dressing products, which approximate a temporary synthetic artificial skin.
Physiology of the acute wound.
  • W. Lawrence
  • Biology, Medicine
    Clinics in plastic surgery
  • 1998
...
...