The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer

@inproceedings{Loh2012TheWS,
  title={The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer},
  author={Yan Ni Loh and Ellen L Hedditch and Laura A Baker and Eve Jary and Robyn Lynne Ward and Caroline Elizabeth Ford},
  booktitle={BMC Cancer},
  year={2012}
}
Acquired resistance to Tamoxifen remains a critical problem in breast cancer patient treatment, yet the underlying causes of resistance have not been fully elucidated. Abberations in the Wnt signalling pathway have been linked to many human cancers, including breast cancer, and appear to be associated with more metastatic and aggressive types of cancer. Here, our aim was to investigate if this key pathway was involved in acquired Tamoxifen resistance, and could be targeted therapeutically. An… CONTINUE READING

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