The Wnt signalling cascade and the adherens junction complex in craniopharyngioma tumorigenesis.

@article{Preda2015TheWS,
  title={The Wnt signalling cascade and the adherens junction complex in craniopharyngioma tumorigenesis.},
  author={Veronica A Preda and Sarah Jane Larkin and Niki Karavitaki and Olaf Ansorge and Ashley B. Grossman},
  journal={Endocrine pathology},
  year={2015},
  volume={26 1},
  pages={1-8}
}
Craniopharyngiomas are epithelial, sellar tumours with adamantinomatous (aCP) and papillary (pCP) subtypes. The aCP type usually occurs during childhood and pCP in middle-aged adults; aCPs often contain mutations in CTNNB1, encoding β-catenin, a component of the adherens junction and a mediator of Wnt signalling. No such mutational event has been associated with pCPs, where the BRAF gene appears to be more important. In a large series of 95 craniopharyngiomas, we show that the aCP subtype… CONTINUE READING
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