The Wnt signaling pathway and its role in tumor development

  title={The Wnt signaling pathway and its role in tumor development},
  author={Barbara Lustig and J{\"u}rgen Behrens},
  journal={Journal of Cancer Research and Clinical Oncology},
Cancer development depends on the aberrant activation of signal transduction pathways that control cell growth and survival and play important roles in normal embryonic development. This review will focus on one of the most powerful pathways, the canonical Wnt signal transduction cascade, which has been originally described in vertebrate and non-vertebrate embryogenesis and subsequently associated with the development of a multitude of different tumor types, mainly of gastrointestinal origin… CONTINUE READING
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