The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

@inproceedings{Takashima2011TheWA,
  title={The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells},
  author={Shuichiro Takashima and Masanori Kadowaki and Kazutoshi Aoyama and Motoko Koyama and Takeshi Oshima and Kazuma Tomizuka and Koichi Akashi and Takanori Teshima},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), and damage to the gastrointestinal (GI) tract plays a critical role in amplifying systemic disease. Intestinal stem cells (ISCs) play a pivotal role not only in physiological tissue renewal but also in regeneration of the intestinal epithelium after injury. In this study, we have discovered that pretransplant conditioning regimen damaged ISCs; however, the ISCs rapidly recovered and… CONTINUE READING

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Paneth cells in gut GVHD: a Panglossian perspective.

Blood • 2013
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References

Publications referenced by this paper.
Showing 1-10 of 39 references

R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 4 Excerpts
Highly Influenced

The intestinal stem cell.

Genes & development • 2008
View 5 Excerpts
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