The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs.

@article{Briata2003TheWP,
  title={The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs.},
  author={Paola Briata and Cristina Ilengo and Giorgio Corte and Christoph Moroni and Michael G. Rosenfeld and Ching-Yi Chen and Roberto Gherzi},
  journal={Molecular cell},
  year={2003},
  volume={12 5},
  pages={1201-11}
}
The Wnt/beta-catenin pathway rapidly induces the transcription of the cell-type-restricted transcription factor Pitx2 that is required for effective cell-specific proliferation activating growth-regulating genes. Here we report that Pitx2 mRNA displays a rapid turnover rate and that activation of the Wnt/beta-catenin pathway stabilizes Pitx2 mRNA as well as other unstable mRNAs, including c-Jun, Cyclin D1, and Cyclin D2, encoded by critical transcriptional target genes of the same pathway. Our… CONTINUE READING
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