The Wilms tumour gene WT1 in leukaemia.

  title={The Wilms tumour gene WT1 in leukaemia.},
  author={Kathy Pritchard-Jones and Linda King-Underwood},
  journal={Leukemia & lymphoma},
  volume={27 3-4},
The WT1 gene is essential for kidney development and is mutated in some Wilms tumours. It is also expressed at a high level in many acute leukaemias and in some haematopoietic progenitor cells, and mutations have been found in leukaemias. The function of WT1, which is a zinc finger protein and has domains characteristic of transcription factors, is not well… CONTINUE READING