The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin

@article{Lee1999TheWT,
  title={The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin},
  author={Sean-Bong Lee and Karen Huang and Rachel E. Palmer and Vivi B Truong and Doris A. Herzlinger and Kathryn Ann Kolquist and Jenise C Wong and Charles Paulding and Seung Kew Yoon and William L. Gerald and Jonathan Daniel Oliner and Daniel A. Haber},
  journal={Cell},
  year={1999},
  volume={98},
  pages={663-673}
}

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TLDR
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TLDR
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TLDR
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The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1.
TLDR
It is demonstrated here that WT1 and LHX9 function as direct activators of the Sf1 gene, and a pathway in which the products of the Wt1 and Lhx9 genes activate expression of S f1 and thus mediate early gonadogenesis is suggested.
WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.
TLDR
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TLDR
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