The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans

@inproceedings{Wang2013TheWT,
  title={The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans},
  author={Xiao na Wang and Ze Li and Yu Tang Ren and Tao Jiang and Ya Wang and Min Chen and Jun Zhang and Jian Hao and Yan Bo Wang and Ri Na Sha and Yi Huang and Xiao Liu and Jing Hu and Guang Qing Sun and Hong Gang Li and Cheng Xiong and Jun Xie and Zhi Mao Jiang and Zhi Ming Cai and Jun Wang and Jian Wang and Vicki Huff and Yao Ting Gui and Fei Gao},
  booktitle={PLoS genetics},
  year={2013}
}
Azoospermia is one of the major reproductive disorders which cause male infertility in humans; however, the etiology of this disease is largely unknown. In the present study, six missense mutations of WT1 gene were detected in 529 human patients with non-obstructive azoospermia (NOA), indicating a strong association between WT1 mutation and NOA. The Wilms tumor gene, Wt1, is specifically expressed in Sertoli cells (SCs) which support spermatogenesis. To examine the functions of this gene in… CONTINUE READING

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