The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression.

@article{Wagner2014TheWT,
  title={The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression.},
  author={Kay-Dietrich Wagner and Julien Cherfils-Vicini and Naoki Hosen and Peter Hohenstein and Eric Gilson and Nicholas D Hastie and Jean-François Michiels and Nicole Wagner},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={5852}
}
Angiogenesis, activation of metastasis and avoidance of immune destruction are important for cancer progression. These biological capabilities are, apart from cancer cells, mediated by different cell types, including endothelial, haematopoietic progenitor and myeloid-derived suppressor cells. We show here that all these cell types frequently express the Wilms' tumour suppressor Wt1, which transcriptionally controls expression of Pecam-1 (CD31) and c-kit (CD117). Inducible conditional knockout… CONTINUE READING
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